WebPINK1可通过募集并活化parkin引发线粒体自噬；parkin敲除后，PINK1也可通过泛素蛋白磷酸化募集OPTN和NDP52至线粒体，进而诱导低水平线粒体自噬。 PINK1是线粒体自噬发生的主要因子，还可作为衡量线粒体是否损伤的探测器。 检索文章中任意一个作者姓名。如，张三 Web文献「PINK1-Parkin経路はHIF-3alphaの選択的スプライスバリアントであるIPASのユビキチン化と分解を促進する」の詳細情報です。 J-GLOBAL 科学技術総合リンクセンター …
PINK1/Parkin介导的线粒体自噬 - bjmu.edu.cn
WebJan 21, 2015 · PINK1 accumulates on the outer membrane of damaged mitochondria, activates Parkin's E3 ubiquitin ligase activity, and recruits Parkin to the dysfunctional … WebPINK1. PTEN -induced kinase 1 ( PINK1) is a mitochondrial serine/threonine-protein kinase encoded by the PINK1 gene. [5] [6] It is thought to protect cells from stress-induced mitochondrial dysfunction. PINK1 activity causes the parkin protein to bind to depolarized mitochondria to induce autophagy of those mitochondria. reddit screenwriting uk
Mitochondrial Quality Control via the PGC1α-TFEB Signaling ... - PubMed
WebNov 9, 2024 · PTEN-induced kinase 1 (PINK1) and Parkin RBR E3 ubiquitin-protein ligase (PARKIN) signalling play a key role in mitophagy and mitochondrial motility and size. … Web所属 (現在)：順天堂大学,大学院医学研究科,准教授, 研究分野：神経内科学,小区分52024:神経内科学関連,病態医化学,小区分49010:病態医化学関連, キーワード：PINK1,Parkin,パーキンソン病,ミトコンドリア,遺伝性パーキンソン病,ショウジョウバエ,mitophagy,ドーパミン神経,iPS細胞,iPS, 研究課題数：10 ... WebJul 10, 2015 · Mitochondrial injury and dysfunction, a significant feature in metabolic syndrome, triggers endothelial cell dysfunction and cell death. Increasing evidence suggests that mitophagy, a process of autophagic turnover of damaged mitochondria, maintains mitochondrial integrity. PINK1 (phosphatase and tensin homolog (PTEN)-induced … knvb teamindex