Detomidine side effects in horses

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August undefined, 2024

WebFeb 28, 2024 · Each mL of Dormosedan ® contains 10.0 mg detomidine hydrochloride, 1.0 mg methyl paraben, 5.9 mg sodium chloride, and water for injection, q.s.. Clinical Pharmacology Dormosedan ®, a non-narcotic sedative and analgesic, is a potent α 2-adrenoreceptor agonist which produces sedation and superficial and visceral analgesia … WebDetomidine hydrochloride is tolerated in horses at up to 200 mcg/kg of body weight (10 times the low dosage and 5 times the high dosage). In safety studies in horses, detomidine hydrochloride at 400 mcg/kg of body weight administered daily for 3 consecutive days produced microscopic foci of myocardial necrosis in 1 of 8 horses.

Equine NSAIDs and Analgesics – Large Animal Surgery – …

WebDetomidine is yet another alpha-2 agonist with even longer duration effects. Detomidine does a better job of balancing the horse’s weight (4 point stance) and is safe to use when working on the hindlimbs. ... Dose iv or im: 2-4 ml (10mg/ml) for 1000# horse. Side effects: Ace is safe in most horses. Caution is needed in stallions and those ... dutch oven 1l

Equine Colic - an overview ScienceDirect Topics

WebDORMOSEDAN ® GEL (detomidine hydrochloride) is a helping hand when horse handlers need it. Available with a veterinarian’s prescription in single-dose syringes, this oromucosal gel is administered under the horse’s tongue a minimum of 40 minutes prior to starting the horse care activity. This formulation is convenient and safe for use ... WebDetomidine was administered throughout 10 pregnancies in eight mares. An intravenous injection of 20 micrograms/kg body weight was given weekly from Day 14 to Day 60 of gestation and thereafter every four weeks until parturition. One mare suffered torsion of the large colon and was destroyed on Day … WebThe cardiovascular effects of xylazine and detomidine in horses were studied. Six horses were given each of the following 5 treatments, at 1-week intervals: xylazine, 1.1 mg/kg, IV; xylazine, 2.2 mg/kg, IM; detomidine, 0.01 mg/kg, IV; detomidine, 0.02 mg/kg, IV; and detomidine, 0.04 mg/kg, IM. All treatments resulted in significantly decreased ... dutch oven 2l

Detomidine Hydrochloride - Modern Veterinary Therapeutics

(detomidine hydrochloride) - Zoetis US

WebOct 2, 2024 · Allowing the horse to stand quietly for 5 minutes before administration and for 10-15 minutes after injection may improve the response to Detomidine Hydrochloride. Detomidine Hydrochloride is a potent α 2 -agonist, and extreme caution should be exercised in its use with other sedative or analgesic drugs for they may produce additive … WebFeb 29, 2016 · Common sedatives include xylazine (Rompun), detomidine (Dormosedan) and romifidine (SediVet). All of these drugs are short-acting and provide some pain relief with their sedation. dutch outletsWebhorses. However, all have the potential to produce signiﬁcant side effects, especially when used at high doses. Although not approved for use in horses in the United States, the newer NSAIDs like meloxi-camd (0.6 mg/kg, IV) and carprofene (0.7 mg/kg, IV) may have fewer side effects with good efﬁcacy. Transdermal 1% diclofenacf may have the ... in 1st class

"WebJul 17, 2024 · Many owners wonder whether sedation is safe for pregnant mares. “The common sedatives used in horses are α2 agonists (xylazine and detomidine),” says Linton. “Many people also use ... " - Detomidine side effects in horses

Detomidine side effects in horses

Practical Standing Chemical Restraint of the Horse - AAEP

WebEach mL of DORMOSEDAN GEL contains 7.6 mg detomidine hydrochloride. The chemical name is 1H imidazole, 4- [ (2,3-dimethylphenyl) methyl]-hydrochloride. Detomidine hydrochloride is a white, crystalline, water-soluble substance having a molecular weight of 222.7. The molecular formula is C 12 H 14 N 2 •HCl and the structural formula is. WebLike xylazine, detomidine causes a minimal fall in equine PaO 2 (Clarke, 1988), but marked hypoxaemia in sheep (Waterman et al., 1986). In horses, other side effects include muscular twitching, sweating, piloerection, hyperglycaemia, a marked diuresis and reduced gut motility. Side effects increase in frequency and duration with increased dose.

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WebSemantic Scholar extracted view of "A Preliminary Trial of Detomidine/Opiate Combination in the Horse" by B. Paton et al. ... Fourteen clinical cases were successfully sedated using detomidine/butorphanol combinations, and side effects seen were increased ataxia (greatest following methadone and butorphanol) and excitement (usually muzzle ... WebDetomidine (detomidine hydrochloride) is an α-2 sedative analgesic that is used primarily in horses. It produces a dose-dependent sedative and analgesic effect, but it also has cardiac and respiratory effects. Detomidine is well absorbed after oral administration, but due to a high first-pass effect, little is available systemically.

Webhorse. The best index of the degree of sedation with acepromazine is the presence of protrusion of the penis in male horses. In addition, the eyelids will droop, and the third eyelid will protrude. Phe-nothiazine tranquilizers interfere with platelet func-tion, and thus, their use should be avoided if this is a concern.6 Hypovolemic horses ... WebWith detomidine administration, heart rate is markedly decreased, blood pressure is initially elevated, and then a steady decline to normal is seen. A transient change in the conductivity of the cardiac muscle may occur, as evidenced by partial atrioventricular (AV) and sinoauricular (SA) blocks.

WebThe effects of administration of one of four opiates (pethidine 1 mg/kg bodyweight (bwt), morphine 0.1 mg/kg bwt, methadone 0.1 mg/kg bwt, and butorphanol 0.05 mg/kg bwt) given intravenously to horses and ponies already sedated with detomidine (10 micrograms/kg bwt) were investigated. Behavioural, c … WebDetomidine is an imidazole derivative and α 2-adrenergic agonist, [citation needed] used as a large animal sedative, primarily used in horses.It is usually available as the salt detomidine hydrochloride.It is a prescription medication available to veterinarians sold under various trade names.. Currently, detomidine is licensed for use only in horses in …

WebApr 7, 2024 · Foals were sedated using sublingual detomidine hydrochloride at a dosage of 0.08 mg/kg to avoid stress associated with injectable sedation. Once foals appeared sedated with their heads low to the ground and with wide base stance (30 minutes), topical lidocaine hydrochloride was applied at the determined locations of EEG electrodes.

WebFeb 20, 2024 · Available to veterinarians as detomidine hydrochloride, detomidine is a selective α-2 adrenoreceptor agonist used in horses as a sedative to assist in performance of a variety of clinical procedures. In addition, it is used as an analgesic in the treatment of abdominal pain (colic). Detomidine activates α-2 catecholamine receptors, which ... dutch oven 4lWebOct 16, 2013 · The most common legitimate use in horses is for long-term sedation for enforced rest when recovering from injury, and for this purpose it is very helpful. ... Different horses vary greatly in their sensitivity to the … in 1st octoberWebJun 29, 2024 · Side Effects Horses treated with Detomidine Hydrochloride exhibit hypertension. Bradycardia routinely occurs 1 minute after injection. The relationship between hypertension and bradycardia is consistent with an adaptive baroreceptor response to the increased pressure and inconsistent with a primary drug-induced bradycardia. … dutch oven alansonhttp://modernveterinarytherapeutics.com/detomidine-hydrochloride/ dutch oven alanson miWebDetomidine hydrochloride is tolerated in horses at up to 200 mcg/kg of body weight (10 times the low dosage and 5 times the high dosage). In safety studies in horses, detomidine hydrochloride at 400 mcg/kg of body weight administered daily for 3 consecutive days produced microscopic foci of myocardial necrosis in 1 of 8 horses. dutch oven 18 literWebbeen established. Detomidine in this regard has been regarded better alternative both in cows and mares. Detomidine • More popular in Europe (cheaper than xylazine) • Duration of sedation longer acting than xylazine (twice), lasting at least 45 min • 5 - 20 mcg/kg IV • Similar side effects in all other aspects with xylazine • in 2 a ft 2 conversionWebThe death rate for healthy horses that undergo procedures using anesthesia is 0.9% and this is increased to 1.9% in sick horses. Elective procedures should be performed only in healthy horses. Food should be withheld for 6-12 hours prior to surgery and horse allowed free access to water. The longer food is withheld, the more likely GI upsets ... in 2 a m 2