WebMar 6, 2024 · Mechanistically, TUBB2B induces the expression of CYP27A1, an enzyme responsible for the conversion of cholesterol to 27-hydroxycholesterol, which leads to the up-regulation of cholesterol and... WebCYP27A1 is a mitochondrial cytochrome P450 which can hydroxylate vitamin D3 and cholesterol at carbons 25 and 26, respectively. The product of vitamin D3 metabolism, 25 …
[Clinical and genetics characteristics of adult-onset ... - PubMed
WebFeb 16, 2024 · It was shown later that MBG is synthesized by the cells of the adrenal cortex and placenta by the transformation of bile acids using one of the enzymes of the P450 cytochrome family, CYP27A1 . MBG selectively interacts with the alpha-1 isoform of Na/K-ATPase, the main isoform of the enzyme in the kidneys and blood vessels, and it is an … WebCYP27A1 Polyclonal Antibody detects CYP27A1 protein at cytoplasm in human endometrial carcinoma by immunohistochemical analysis. Sample: Paraffin-embedded human endometrial carcinoma. CYP27A1 Polyclonal … orchard breezin blush crush
PXR induces CYP27A1 and regulates cholesterol metabolism in …
WebCYP27A1 belongs to the mitochondrial CYPs and plays a crucial role in the cholesterol homeostasis. Analysis of ~60,000 human exomes points to underdiagnosis of … WebOct 28, 2024 · Sterol 27-hydroxylase (CYP27A1) is a key enzyme in bile acids (BAs) biosynthesis and a regulator of cholesterol metabolism. Cyp27a1/Apolipoprotein E double knockout (DKO) mice fed with western diet (WD) are protected from atherosclerosis via up-regulation of hepatic Cyp7a1 and Cyp3a11. WebApr 2, 2024 · CYP27A1 is lost in prostate cancer and predictive of progression. A, TCGA was queried for mRNA levels of CYP27A1 in tumor samples and Gleason score at the time of diagnosis. Patients whose tumors have a Gleason score >7 have significantly lower levels of expression of CYP27A1 than ips weather