WebDec 22, 1998 · Nucleotides −6500 to +34 of the mouse cryptdin-2 gene were used to direct expression of simian virus 40 T antigen to a subset of neuroendocrine cells in all lobes of the FVB/N mouse prostate. Transgene expression is initiated between 7 and 8 weeks of age and leads to development of prostatic intraepithelial neoplasia within a week. WebOct 1, 1999 · In mice, Paneth cell α-defensins are termed cryptdins (crypt defensins) (5–7), of which six distinct peptides have been isolated and characterized ( 6 ). Cryptdins and other antimicrobial molecules (lysozyme and secretory phospholipase Α2) are released from secretory granules in response to bacteria or cholinergic agents ( 6, 8 ).
Synergism in dual functionality of cryptdin-2 in conjunction with ...
WebSep 1, 2014 · Cryptdin-2-ciprofloxacin, cryptdin-2-ceftriaxone and cryptdin-2-cefotaxime combinations were found synergistic as evident by in vitro assays. This synergism … WebDesign The anatomical distribution as well as antibacterial and anti-inflammatory activity of the endogenous AMP cryptdin 2 and the synthetic peptide Pep19-2.5 at the enteric mucosal surface were analysed by … each child care
Secretion of microbicidal α-defensins by intestinal Paneth ... - Nature
WebJan 13, 2024 · Background A number of antimicrobial peptides (AMPs) hold promise as new drugs owing to their potent bactericidal activity and because they are often refractory to the development of drug resistance. Cryptdins (Crps) are a family of antimicrobial peptides found in the small intestine of mice, comprising six isoforms containing three sets of … WebJun 15, 1992 · Abstract. We have purified and determined the amino acid sequence of cryptdin-1, a murine Paneth cell defensin. The peptide corresponds to a previously characterized mRNA that accumulates to high abundance during postnatal ontogeny of the small bowel. Acid-extracted intestinal protein was fractionated by cation-exchange … each child had to a short