Cancer testis antigens
WebOf all the tumor-associated antigens, cancer/testis antigens (CTAs) are of particular interest as a potential target for immunotherapy because of their strong in vivo immunogenicity and unique expression patterns. 3. CTAs belong to a group of proteins that are expressed in the developing embryo, ... Cancer/testis (CT) antigens are a group of proteins united by their importance in development and in cancer immunotherapy. In general, expression of these proteins is restricted to male germ cells in the adult animal. However, in cancer these developmental antigens are often re-expressed and can serve as a … See more With the development of tumor-associated antigens (TAA), the first clone of a human tumor antigen, melanoma antigen-1 (MAGE-1) was reported in 1990s, which elicited an autologous cytotoxic T-lymphocyte (CTL) … See more Germ cells share some features with cancers. The motile and penetrating features and colonization of primitive germ cells resemble the migration of cancer cells from primary … See more CT antigens can be divided by whether they are encoded on the X chromosome (X-CT antigens genes) or not (non-X-CT antigens genes). It has been estimated that 10% of genes … See more The expression of CT antigens genes are exclusively regulated by epigenetic events both in normal and cancer tissues, while DNA methylation and histone post-translational … See more Immunogenicity In normal tissues, CT antigens are exclusively expressed in testis, making it no access to the … See more
Cancer testis antigens
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WebApr 10, 2024 · The chemical complementarity of glioblastoma, tumor-resident T-cell receptors and cancer testis antigens were associated with a worse outcome. Additionally, the high expression of immune marker and low expression of apoptosis genes were associated with a high T-cell receptor–cancer testis antigen chemical complementarity … WebApr 10, 2024 · PDF Introduction. Glioblastoma (GBM) is the most aggressive primary brain tumor in adults. Despite a growing understanding of glioblastoma pathology,... Find, read and cite all the research ...
WebJul 7, 2016 · Cancer testis antigens (CTAs) have attracted the attention of cancer researchers as potential mediators of cancer cell recognition (15, 16). The members of this group are expressed in a wide range of cancers, including lung cancer, while in normal tissues their expression is restricted to immune privileged sites, such as testis and … WebJan 14, 2009 · The CTdatabase facilitates both the mining of the existing deluge of data about cancer-testis (CT) antigens, and the identification of proteins alleged to be CT antigens, but that do not have their characteristic restricted expression pattern. Carefully curated and annotated with most data being specifically processed for CT antigens and …
WebJan 1, 2024 · A gene is generally considered to be a CG antigen if it is expressed in the gametogenic cells of the testis or ovary (including fetal ovary) and in some proportion of human cancers, but is expressed in two or fewer normal somatic tissues. CG antigen genes are also commonly expressed in trophoblast tissue. CG antigens were originally … WebCancer-testis antigens are antigens expressed primarily in the germ cells of the testes, but also in fetal ovaries and the trophoblast. Some cancer cells aberrantly express these …
WebMay 11, 2024 · The cancer/testis antigen gene VCX2 is rarely expressed in malignancies but can be epigenetically activated using DNA methyltransferase and histone deacetylase inhibitors. Front.
WebSep 25, 2006 · Cancer-testis antigens (CTA), a family of tumor-associated antigens, have both potent immunogenicity and restricted expression patterns in normal adult tissues, highly desirable characteristics for targets of anticancer vaccines. These antigens were evaluated for both the degree of expression and prognostic value in cancer of the urothelium. litehouse hobart indianaWebJun 9, 2016 · Roles of LEM domain containing 1 (LEMD1), a novel cancer–testis antigen, in OSCCs are unclear. We performed immunohistochemical analysis of LEMD1 in 289 OSCC patients and examined functions of ... impetigo on chinWebJan 1, 2006 · Abstract. CT10/MAGE-C2 is a recently identified antigen that, typically of cancer/testis (CT) antigens, can be found in various malignant tumors and in normal adult testis. As with many other CT antigens, our knowledge is based mainly on mRNA expression data. In the present study, we describe the generation of mAbs to … impetigo of the scalp school outbreakWebApr 27, 2024 · Lung cancer is the leading type of malignant tumour among cancer-caused death worldwide, and the 5-year survival rate of lung cancer patients is only 18%. … litehouse homestyle ranch dressing caloriesWebJan 1, 2004 · Abstract. Sarcomas are rare but aggressive malignant tumors associated with high mortality, for which the efficacy of standard therapies remains limited. In order to develop immunotherapeutic approaches for the treatment of sarcoma, we studied the relevance of cancer/testis antigens (CTAs), a group of antigens whose expression is … litehouse hurricaneWebCancer/testis antigens (CTAs) are named based on their expression pattern that is restricted in a number of normal and abnormal tissues. Tumor cells frequently express … impetigo on child\u0027s faceWebApr 10, 2024 · The chemical complementarity of glioblastoma, tumor-resident T-cell receptors and cancer testis antigens were associated with a worse outcome. … impetigo of the scalp