Calsyntenin-1

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August undefined, 2024

WebCalsyntenin 1 binds to the kinesin light chain via its light chain-1 binding motifs and acts as an adaptor protein between APP and kinesin-1, which is supported by its colocalization with APP in ... WebCalsyntenin-1(CLSTN1) plays a critical role in the nervous system, but its relevance in cardiovascular diseases is unknown. We investigated the significance of CLSTN1 in doxorubicin-induced DCM. Methods: CLSTN1 expression in doxorubicin-induced DCM rats and H9c2 cells was determined using western blotting. To further explore the functions of ...

Custom Human Calsyntenin-1 IQELISA™ Kit RayBiotech

WebAug 15, 2012 · Here we characterized the function of calsyntenin-1 in neuronal APP transport using selective immunoisolation of intracellular trafficking organelles, … Web胎牛血清（杂交瘤细胞专用） sp2/0 小鼠骨髓瘤细胞. 佐剂乳化器 tlso with hip spica

Calsyntenin-1, a proteolytically processed postsynaptic membrane ...

WebCalsyntenin-1 is a neuronally enriched type-1 membrane-spanning protein that binds directly to KLCs via its intracellular C-terminal domain (13–16). As such, calsyntenin-1 … WebMar 29, 2024 · Calsyntenin 1-mediated trafficking of axon guidance receptors regulates the switch in axonal responsiveness at a choice point. Development. 2016;143:994–1004. doi: 10.1242/dev.127449. Liu H, Thurig S, Mohamed O, Dufort D, Wallace VA. Mapping canonical Wnt signaling in the developing and adult retina. Invest Ophthalmol. WebDec 31, 2024 · Calsyntenin-1 directly correlated with global pathological tau burden in FTLD (r 2 =.22; p=0.005) and in “pure FTLD” (r 2 =.17; p=0.02). Conclusion Low CSF levels of the post-synaptic modulator, Calsyntenin-1, is specific to FTLD, particularly in cases with little or no tau pathology and could aid the early diagnosis of FTD and the ... tlso232

[The family of calsyntenins: learning and memory related genes]

Cognitive Deficits in Calsyntenin-2-deficient Mice Associated with ...

WebJun 27, 2012 · In accordance with the identification of calsyntenin-1/APP vesicles as a distinctive carrier for anterograde axonal transport of APP we found that calsyntenin-1 and APP exit the TGN together in a vesicle with early-endosomal characteristics (Ludwig et al., 2009) and that all calsyntenin-1 vesicles are transported anterogradely along axons ... WebJan 1, 2001 · We termed this protein calsyntenin-1, because it binds synaptic Ca 2+ with its cytoplasmic domain. By binding Ca 2+, calsyntenin-1 may modulate Ca 2+-mediated … tlso with shoulder strapsWebSep 22, 2024 · This gene is a member of the calsyntenin family, a subset of the cadherin superfamily. The encoded transmembrane protein, also known as alcadein-alpha, is … tlso with thigh cuff

"WebCalsyntenin-1 (CST-1; gene name CLSTN1), also called Alcadein-alpha, is a 140‑150 kDa type I transmembrane glycoprotein that is member of the Alcadein family of cadherin … " - Calsyntenin-1

Calsyntenin-1

Web十二烷基硫酸钠Cas 号：【151-21-3】M D L：--MFCD00036175分子式：C12H25O4NaS； CH3（CH2）11OSO3Na分子量：288.38别 &nbs

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WebMar 20, 2012 · Calsyntenin-1 is a neuronally enriched type-1 membrane-spanning protein that binds directly to KLCs via its intracellular C-terminal domain (13– 16). As such, calsyntenin-1 acts as a ligand to mediate transport of a subset of vesicles through axons on kinesin-1 motors. WebThe calsyntenin-1 is located in the postsynaptic membrane of CNS synapses and a proteolytically processed protein of the postsynaptic membrane with a calcium-binding cytoplasmic domain. Calsyntenin-1 is a dynamic modulator of postsynaptic calcium by extracellular proteolysis. Calsyntenin-1 may modulate Ca2+ transients locally either …

WebJun 25, 2014 · Calsyntenin-1 is a transmembrane cargo-docking protein important for kinesin-1-mediated fast transport of membrane-bound organelles that exhibits peak expression levels at postnatal day 7. However ... WebJun 25, 2014 · Calsyntenin-1 is a transmembrane cargo-docking protein important for kinesin-1-mediated fast transport of membrane-bound organelles that exhibits peak …

Web开馆时间：周一至周日7:00-22:30 周五 7:00-12:00; 我的图书馆 WebApr 1, 2011 · Calsyntenin-1 was detected through the EGFP tag and KLC1 using the anti-FLAG antibody; images shown are confocal sections. (A) Calsyntenin-1 is highly co-localised with wild-type and both mutant KLC1s in perinuclear regions. In addition calsyntenin-1 and FLAG–KLC1ser460ala co-localise in plasma membrane projections; …

WebApr 1, 2008 · The cytoplasmic region of mammalian calsyntenin-1 binds Ca 2+, and it was proposed that calsyntenins may be involved in proteolysis-dependent modulation of synaptic functions through its Ca 2+-binding capacity (13, 26). Based on this idea, the cytoplasmic region of CASY-1 may be essential for learning in C. elegans.

WebJun 7, 2006 · Calsyntenin-1 Is Enriched in Axonal Growth Cone Vesicles. The presence of calsyntenin-1–containing organelles in developing axons led us to presume that these … tlsp packingWebRayBio® Human Calsyntenin-1 (Alcadein-alpha) ELISA Kit. 4 - 7 week lead time. This ELISA uses an antibody pair and standard that have been validated for multiplex array … tlsokc.comWebJul 1, 2012 · Calsyntenin-1 is a ligand for kinesin-1 light chains and APP is transported through axons on kinesin-1 molecular motors. Defects in axonal transport are an early … tlsp crackWebJul 9, 2014 · Here we identify a kinesin adaptor, Calsyntenin-1 (Clstn-1), as an essential regulator of axon branching and neuronal compartmentalization in vivo. We use morpholino knockdown and a Clstn-1 mutant to show that Clstn-1 is required for formation of peripheral but not central sensory axons, and for peripheral axon branching in zebrafish. tlsp shirtWebApr 8, 2009 · Calsyntenin‐1 recruits KLC1 to the TGN and to post‐Golgi organelles. As Kinesin‐1 localizes to the Golgi/TGN 10, 12, we hypothesized that calsyntenin‐1 recruits Kinesin‐1 to TGN membranes.To test this, we cotransfected calsyntenin‐1 with enhanced green fluorescent proteins (EGFP) fused to the N‐terminus (EGFP‐Cst1) and … tlsp 5tWebAug 1, 2016 · Calsyntenin-1 has previously been shown to mediate transport of endosomes along microtubules in neurons, through interactions with kinesin light chain-1. Here we demonstrate for the first time, we believe, a similar role for calsyntenin-1 in Huh7 cells, mediating intracellular transport of endosomes. In HCV-infected cells we show that ... tlsp toruńWeb上海谷研实业有限公司供应小鼠elisa试剂盒系列产品,公司具有良好的市场信誉,专业的销售和技术服务团队,凭着多年经营经验,熟悉并了解市场行情,赢得了厂商的认可,欢迎来电来涵洽谈交流! tlsp toolbox